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How does Low Level Light Laser Therapy (LLLT) work

Best to watch this video LLLT explained      [ Other Common Ailments helped by Cold Laser Therapy ]

Like photosynthesis - the correct wavelengths and power of light at certain intensities for an appropriate period of time can increase ATP production and cell membrane perturbation could lead to permeability changes and second messenger activity resulting in functional changes such as increased syntheses, increased secretion and motility changes. Red and near infrared light seem to be the most ideal wavelengths.

Red light acts on the mitochondria and near infrared light on the mitochondria and at the cell membrane. In in-vitro and animal LLLT wound healing studies comparing wavelengths, red consistently is more effective. Shorter wavelengths are not so good, expensive to produce and with poor penetration they are a poor choice. Near infrared light whilst not quite as good do penetrate better than the red wavelengths and are available in higher powers and at low prices. According to live in-vivo experiments at Uniformed Services University Bethesda Maryland (a US military research centre) 810nm is the best penetrating wavelength. It also happens to work well in LLLT nerve regeneration studies they are doing.

Clinical Effects of LLLT

An appropriate dose of light can improve speed and quality of acute and chronic wound healing, soft tissue healing, pain relief, improve the immune system and nerve regeneration. Applications with good RCT evidence include Venous Ulcers, Diabetic Ulcers, Osteoarthritis, tendonitis, Post Herpetic Neuralgia (PHN, shingles) & postoperative pain.

To paraphrase NASA research:

“Low-energy photon irradiation by light in the far-red to near-IR spectral range with low-energy (LLLT) lasers or LED arrays has been found to modulate various biological processes in cell culture and animal models. This phenomenon of photobiomodulation has been applied clinically in the treatment of soft tissue injuries and the acceleration of wound healing. The mechanism of photobiomodulation by red to near-IR light at the cellular level has been ascribed to the activation of mitochondrial respiratory chain components, resulting in initiation of a signaling cascade that promotes cellular proliferation and cytoprotection.”

“A growing body of evidence suggests that cytochrome oxidase is a key photoacceptor of light in the far-red to near-IR spectral range. Cytochrome oxidase is an integral membrane protein that contains four redox active metal centers and has a strong absorbance in the far-red to near-IR spectral range detectable in vivo by near-IR spectroscopy.”

“Moreover, 660–680 nm of irradiation has been shown to increase electron transfer in purified cytochrome oxidase, increase mitochondrial respiration and ATP synthesis in isolated mitochondria, and up-regulate cytochrome oxidase activity in cultured neuronal cells.”

“LED photostimulation induces a cascade of signaling events initiated by the initial absorption of light by cytochrome oxidase. These signaling events may include the activation of immediate early genes, transcription factors, cytochrome oxidase subunit gene expression, and a host of other enzymes and pathways related to increased oxidative metabolism.”

“In addition to increased oxidative metabolism, red to near-IR light stimulation of mitochondrial electron transfer is known to increase the generation of reactive oxygen species. These mitochondrially generated reactive oxygen species may function as signaling molecules to provide communication between mitochondria and the cytosol and nucleus.”

Therapeutic photobiomodulation for methanol-induced retinal toxicity.

Proc Natl Acad Sci U S A. 2003 Mar18; 100(6): 3439-44. Epub 2003 Mar 07